KO-Validated Anti-ALDH1A3 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND

Application
| WB |
|---|---|
| Primary Accession | P47895 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 25GB3800 |
| Calculated MW | Predicted, 56 kDa; observed, 56 kDa |
| Gene Name | ALDH1A3 |
| Aliases | ALDH1A3; Aldehyde Dehydrogenase 1 Family Member A3; Retinaldehyde Dehydrogenase 3; RALDH3; ALDH6; Aldehyde Dehydrogenase 6; Aldehyde Dehydrogenase 1 Family, Member A3; Aldehyde Dehydrogenase Family 1 Member A3; Acetaldehyde Dehydrogenase 6; EC 1.2.1.36; EC 1.2.1; ALDH1A6; RALDH-3; RalDH3; MCOP8 |
| Immunogen | Recombinant protein of human ALDH1A3 |
| Gene ID | 220 |
|---|---|
| Other Names | Retinaldehyde dehydrogenase 3, RALDH-3, RalDH3, 1.2.1.36, Aldehyde dehydrogenase 6, Aldehyde dehydrogenase family 1 member A3, ALDH1A3, ALDH1A3, ALDH6 {ECO:0000303|PubMed:7698756} |
| Name | ALDH1A3 |
|---|---|
| Synonyms | ALDH6 {ECO:0000303|PubMed:7698756} |
| Function | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans- 13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9JHW9}. |
| Tissue Location | Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney |

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